Fig. 5

Pangenome of TM7—Accessory gene clusters include clade-specific and niche-specific markers. The dendrogram in the center of the figure organizes the 4045 gene clusters (GCs) that occurred in more than one genome according to their frequency of occurrence in the 55 TM7 genomes. The 55 inner layers correspond to the 55 genomes, where our MAGs that were associated with tongue and plaque are shown in blue and green, respectively. Previously published oral and environmental genomes are shown in black and brown, respectively. The data points in the 55 concentric layers show the presence of a GC in a given genome, and the outermost circular layer highlights groups of GCs that correspond to the core or to group-specific GCs. Genomes in this figure are ordered according to their phylogenomic organization which is shown at the top-right corner. The two top horizontal layers underneath the phylogenomic tree represent clade and oral-site associations of genomes. The next two layers display coverage statistics for each genome in the HMP oral metagenomes from tongue (blue, top) and supragingival plaque (bottom, green) samples