Fig. 3

Shared and private mutations in major primary and relapse T-ALL clones. a Contribution of different mutational processes to the mutation burden of each T-ALL case in the adult cohort. The contribution to primary-private, relapse-private, and shared clonal mutations are indicated separately in absolute (top panel) and relative (bottom panel) terms. b Molecular evolution of adult T-ALL cases represented in a tree-form showing the number of shared clonal mutations (green trunk), clonal private-primary (blue branch) and clonal private-relapse (orange branch) mutations. Only signature 5 mutations are considered to build the tree (for further explanation see Additional file 2: Fig. S7). The relative length of the trunk and branches is proportional to the number of mutations in the respective group. Patients are sorted by decreasing order of age