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Fig. 1 | Genome Biology

Fig. 1

From: The evolution of relapse of adult T cell acute lymphoblastic leukemia

Fig. 1

Comparison of primary adult and pediatric ALL cases. a Clonal mutation burden (per megabase) of primary T-ALLs of nine cohorts. Red lines represent the median mutation burden of tumors in each cohorts. Tumors are represented as dots, sorted along the x-axis according to their mutation burden. b Mutational profiles of primary ALLs in the nine cohorts in a uniform manifold approximation and projection (UMAP) dimensionality reduction graph (see the “Methods” section). The UMAP was run on a matrix of the counts of all possible tri-nucleotide changes (96) across ALL patients of all cohorts. Each dot represents a patient, colored according to the cohort (top panel) or their age (bottom panel). c Mutational processes active across primary ALL cohorts, represented by their mean (and standard deviation) contribution of the mutation burden of each cohort. SBS1, SBS5, SBS2, SBS9, SBS37, SBS13, SBS36, respectively, single nucleotide substitutions signatures 1,5,2,9,37,13,36. d Rate of mutations of selected frequently mutated cancer genes across primary T-ALL cohorts. Cohorts are clustered according to the similarity in their profile of cancer genes mutation frequency (see the “Methods” section). The total number of patients in each cohort with mutations of each cancer gene is represented by bars at the right side of the graph. Only genes with mutations in at least two patients are included in the plot (for the full list see Additional file 2: Fig. S2 and Additional file 1: Tables S3 and S4)

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