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Fig. 2 | Genome Biology

Fig. 2

From: A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos

Fig. 2

Performance evaluation of MethylTransition. a Box plots showing the estimated parameter values from different cell pairs during human first three cell cycles. Each dot represents the parameter value estimated using a pair of scBS-seq data. All available high-quality published scBS-seq data (more than 20% of all CpG sites detected) were used. b Box plots showing the robustness of MethylTransition’s parameter estimation for datasets with simulated dropout rates from 10 to 90%. c Graph showing the biological meaning of MethylTransition’s parameter estimation for a series of simulated DNA methylation transition conditions (gradually changes from decreasing condition to equilibrium condition and then to increasing condition)

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