Fig. 3
From: Pathway information extracted from 25 years of pathway figures
Major milestones in the development of the Hippo signaling pathway. A timeline spanning 1995 to 2013 focuses on the discovery of the components and processes of the Hippo signaling pathway (below timeline), illustrated by representative pathway figures that grow in complexity and detail (above timeline). The events depicted in gray below the timeline were collected mostly from Kim et al. [37]. Drosophila and human orthologs are Wts:LATS1/2, Sav:SAV1, Hpo:MST1/MST2(STK3), Mer:NF2, Fat: FAT1, Ex: FRMD6, Yorkie/Yki:YAP(YAP1)/TAZ(WWTR1), Sd:TEAD1-4, Kibra:WWC1