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Fig. 4 | Genome Biology

Fig. 4

From: Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

Fig. 4

Differential signaling pathways in metastasis and immunohistochemical assessment of leukocyte antigens. a Unsupervised clustering of gene expression profiles using highly variable genes (standard deviation > 2.0; n = 4139). The complete linkage and 1-correlation distance metric were used. Each row represents a gene, and each column represents a sample. Tumor versus normal: T, tumor; N, normal. Tissue type: P, primary tumor; M, metastasis; PN, adjacent normal lung; MN, metastasis adjacent normal tissue. Organ: L, lung; B, brain; H, liver. b Upregulated and downregulated pathways in metastasis (nominal p < 0.01 and q < 0.25). Pathways in red are upregulated pathways in metastasis, and pathways in blue are downregulated pathways in metastasis. c Comparison of immune cell infiltration between primary NSCLC tumors and paired metastases by immunohistochemistry (IHC) of immune markers (CD3, CD4, CD8, CD20, and PD1). The density was defined as the number of cells positive for each marker per square millimeter. The y axis shows the ratio (log2) of density of each cell type in metastases versus that in paired primary lung cancers

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Genome Biology

ISSN: 1474-760X

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