Fig. 3

DNA methylation similarity between primary tumors and paired metastases. a Unsupervised clustering of all samples including normal tissues based on DNA methylation level of all CpG islands (n = 27,000). b Correlation of promoter DNA methylation between primary tumors and metastases for the 1084 genes showing a negative correlation between DNA methylation and gene expression (Spearman’s rank correlation ≤ − 0.5 based on the data in our main cohort). c Correlation of promoter DNA methylation level between primary tumors and metastases for the 521 genes previously reported to be regulated by DNA methylation in NSCLC from the study examining 73 cell lines