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Fig. 4 | Genome Biology

Fig. 4

From: Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens

Fig. 4

Synthetic lethal paralogs. a Overlap of 24 hits with zdLFC < − 3 in any of the three cell lines. b Heatmap showing zdLFC score for the 24 hits. c DDX19A gene essentiality (BF) vs. DDX19B gene expression (logTPM) in Avana data. d Selected co-complex interactions in CCR4-NOT complex shows gene essentiality of several subunits and synthetic lethality of nonessential, alternate subunits CNOT7/CNOT8. e Co-complex interactions of COPS9 signalosome complex, showing strong gene essentiality of required components and synthetic lethality of alternate subunits COPS7A/COPS7B. f Synthetic lethality of CCNE1/CCNE2 in OVCAR8 cells, where CDK2 is highly essential. g Synthetic lethality of CCNT1/CCNT2, not shown in B (zdLFC = − 2.6), and essentiality of CDK9

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