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Fig. 2 | Genome Biology

Fig. 2

From: Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens

Fig. 2

Computational detection of constitutively-expressed paralog buffering. a Method overview: loss of function in one paralog gives rise to gene essentiality in the other. Chart indicates number of pairs testable by this method. b Summary of results by dataset. c Overlap between Sanger (Project Score) and Broad (DepMap) computationally derived synthetic lethals. dg Scatter plots of Bayes Factors of paralog pairs, with loss of function (LOF) labeled

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