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Fig. 4 | Genome Biology

Fig. 4

From: Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions

Fig. 4

Bex3 mutant mice display an array of behavioral and cognitive alterations. Adult control and Bex3 mutant mice were subjected to a comprehensive battery of behavioral tests. a Locomotor activity (number of broken beams) and total repetitive behaviors (number of grooming and rearing) were evaluated in a 5-min open field test. b Social behavior was assayed in the three-chambered test. Sniffing times are showed in social familiar and social stranger phases. c Social organized behaviors were tested by the nesting building assay. d Sensory motor integration was determined by prepulse inhibition of acoustic reflex. e The Y-maze test was performed to evaluate repetitive conducts, attention, and/or working memory. As alternance, the % of triplets was determined. f Novel object recognition memory was evaluated 24 h after a training session. A positive discrimination index in this memory test indicates novel object preference exploration. g The passive avoidance test was used to evaluate emotional cognition. Entry latencies to the dark compartment in training and memory testing sessions are shown. Results are presented as mean ± SEM (N = 6 mice per experimental group); *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001, one-way ANOVA

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