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Fig. 3 | Genome Biology

Fig. 3

From: COCOA: coordinate covariation analysis of epigenetic heterogeneity

Fig. 3

COCOA can be used for region-based data such as ATAC-seq. a The COCOA score for each region set, ordered from highest to lowest. The ER-related group includes GATA3, FOXA1, and H3R17me2. For definition of the hematopoietic TF group, see the section “Region set database” in the “Methods” section. b The association of PC scores with ER status for PCs 1–4 based on a Wilcoxon rank-sum test. c Meta-region profiles of the two highest scoring region sets from PC1 (GATA3, ER) and PC2 (CEBPA, ERG). Meta-region profiles show correlation between PC scores and the epigenetic signal in regions of the region set, centered on the regions of interest. A peak in the center indicates that chromatin accessibility in those regions correlates with the PC specifically around the sites of interest. The number of regions from each region set that were covered by the epigenetic data in the COCOA analysis (panel a) is indicated by “n

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