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Fig. 3 | Genome Biology

Fig. 3

From: sgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine

Fig. 3

Comparison between base editing of APOBEC1-derived sgCBE and other deaminase-derived sgCBEs. a Architectures of sgCBEs. b Efficiency of cytosine editing with sgCBE derived from various cytosine deaminases. HEK293T cells were transfected with various sgCBEs targeting a set of three different sites. C-to-T editing efficiencies were analyzed by Sanger sequencing and EditR calculating. Each experiment was repeated at least three times. Data are represented as mean ± SEM

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Genome Biology

ISSN: 1474-760X

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