Fig. 5

Evaluation of feature selection methods. a Ability of different feature ranking methods to capture genes with a high proportion of variance (left) or deviance (right) explained by real subpopulations. The asterisk denotes the default Seurat method. b Accuracy of clusterings (at the true number of clusters) when selecting 1000 genes using the given methods. Based on standard Seurat normalization (left) or sctransform (right). The vst.varExp and devianceExplained methods correspond to the estimates used in a to evaluate the selection methods and were included here only for validation purpose