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Fig. 5 | Genome Biology

Fig. 5

From: sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

Fig. 5

Enrichment of TFBS for u-eQTLs and ts-eQTLs. a Number of TFs whose binding sites are enriched for eQTLs across factors at FDR < 0.05 for sn-spMF, flashr bf, and heuristic 1 methods. Enh, enhancers; TssA, active transcription start sites. b Total number of TFs with binding sites enriched for either only u-eQTLs, or only ts-eQTLs, or both. c Distribution of the number of tissue-specific factors each TF is enriched in. df Enrichment for example TFs among eQTLs across each factor (− log10(P value)) where the TF was expressed in corresponding tissues for d FOSL2, e GATA4, and f HNF4A. Black bars represent that the BH-corrected P value is < 0.05

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