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Table 1 Average estimates of \(\hat {\pi }\)

From: Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Scenario Method πk(%)  
   qk = (0 0 0) (1 0 0) (0 1 0) (0 0 1) (1 1 0) (1 0 1) (0 1 1) (1 1 1)
1a   Independent  
  True 99.720 0.070 0.070 0.070 0.020 0.020 0.020 0.010
  Primo(t) 99.712 0.074 0.074 0.074 0.019 0.019 0.019 0.010
  Primo(P) 99.749 0.065 0.065 0.065 0.016 0.016 0.016 0.007
   Correlated  
  True 99.720 0.070 0.070 0.070 0.020 0.020 0.020 0.010
  Primo(t) 99.712 0.073 0.073 0.073 0.019 0.019 0.019 0.011
  Primo(P) 99.749 0.065 0.065 0.065 0.016 0.016 0.016 0.007
1b   Independent  
  True 99.839 0.070 0.070 0.0007 0.020 0.0002 0.0002 0.0001
  Primo(t) 99.832 0.073 0.073 0.0031 0.019 0.0002 0.0002 0.0001
  Primo(P) 99.857 0.063 0.063 0.0014 0.016 0.0002 0.0001 0.0001
   Correlated  
  True 99.839 0.070 0.070 0.0007 0.020 0.0002 0.0002 0.0001
  Primo(t) 99.832 0.073 0.072 0.0029 0.019 0.0002 0.0002 0.0001
  Primo(P) 99.857 0.063 0.063 0.0013 0.016 0.0002 0.0002 0.0001
  1. Scenario 1a simulates sparse associations for J=3 traits. Scenario 1b simulates even sparser associations for the third trait