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Fig. 3 | Genome Biology

Fig. 3

From: Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Fig. 3

An example of a known breast cancer susceptibility locus being associated with multi-omics traits. At a posterior probability threshold of 80%, Primo identified SNP rs2992756 as being associated with all four omics traits for the gene KLHDC7A. Here shows the − log10(P) values by position on chromosome 1 in the region of the gene KLHDC7A for all SNPs including the breast cancer susceptibility locus (rs2992756, red dot) in GWAS (top panel) and eQTL, meQTL, and pQTL analyses in tumor tissue (the next three panels, respectively) and eQTL analysis in normal tissue (bottom panel) for the gene and protein KLHDC7A and CpG site cg05040210

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Genome Biology

ISSN: 1474-760X

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