Table 2 Genes significantly associated with lipid traits in at least one test on the ESP
Trait | Gene | Pval PSCAN-M | Pval PSCAN-V | Pval SCAN1D-M | Pval SCAN1D-V | Pval Burden | Pval SKAT | #SNP Total | #Signal SNP in (PSCAN-M,-V), (SCAN1D-M,-V), SV |
|---|---|---|---|---|---|---|---|---|---|
HDL | CD36 | 1.2×10−6 | 2.6×10−7 | 9.0×10−3 | 3.9×10−7 | 2.7×10−4 | 1.1×10−7 | 70 | (2,2), (0,48), 1 |
|  | CETP | 6.9×10−7 | 2.4×10−9 | 7.0×10−9 | 1.1×10−9 | 4.9×10−4 | 9.1×10−8 | 35 | (3,4), (2,3), 1 |
|  | NCK1 | 3.6×10−1 | 6.5×10−6 | 4.0×10−1 | 2.4×10−6 | 2.5×10−1 | 6.2×10−6 | 12 | (0,12), (0,7), 1 |
|  | PCSK7 | 1.8×10−6 | 1.8×10−6 | 2.6×10−6 | 1.7×10−6 | 1.4×10−1 | 2.4×10−3 | 28 | (1,1), (1,1), 1 |
TRIG | APOC3 | 1.5×10−5 | 1.2×10−5 | 3.6×10−8 | 1.1×10−5 | 3.9×10−6 | 3.2×10−6 | 7 | (7,7), (4,4), 2 |
|  | ARSI | 1.4×10−1 | 1.5×10−5 | 6.1×10−1 | 1.9×10−1 | 7.3×10−2 | 4.0×10−2 | 28 | (0,9), (0,0), 0 |
|  | CYP2C9 | 4.4×10−6 | 4.0×10−2 | 5.1×10−5 | 4.6×10−2 | 6.4×10−7 | 1.6×10−2 | 33 | (30,0), (16,0), 0 |
|  | NFATC1 | 3.3×10−2 | 1.4×10−7 | 5.6×10−2 | 1.5×10−6 | 1.7×10−1 | 5.9×10−2 | 35 | (0,6), (0,7), 0 |
|  | PGM1 | 2.8×10−4 | 9.9×10−6 | 2.3×10−1 | 2.9×10−1 | 9.9×10−1 | 7.2×10−2 | 27 | (3,3), (0,0), 1 |