Fig. 3
Power comparisons of PSCAN-M, PSCAN-V, SCAN1D-M, SCAN1D-V, burden and SKAT tests. Each bar represents the empirical power estimated as the proportion of p-values less than 10−6. The left panel assumes unidirectional genetic effects and the right panel assumes bidirectional effects; the upper panel assumes 10% of the variants are causal and the lower panel assumes 50% of the variants are causal. For each configuration, low (ρ=0.1), medium (ρ=0.25) and high (ρ=1) dispersion levels of signal variants are considered