Fig. 1
From: GBAT: a gene-based association test for robust detection of trans-gene regulation
Schematic of the GBAT pipeline. First, GBAT predicts the expression levels from cis genetic variants (cross-validated cis-genetic prediction of gene i (CVGPi)) using cvBLUP. Then, GBAT performs gene-based association tests between CVGPi and expression level of gene j to identify gene-based trans-association, while properly includes supervised SVA conditional on each CVGPi (SVi) as covariates