Fig. 5
a CDCA7 (located on chromosome 2) and CDCA7L (located on chromosome 7) both affect genome-wide DNA methylation levels. Blue lines indicate a positive association between CDCA7 expression and trans DNA methylation levels. Green lines indicate a positive association between CDCA7L expression levels and trans DNA methylation levels. b, c Over- or underrepresentation of target CpGs in predicted chromatin states for b CDCA7 and c CDCA7L. Blue bars represent enrichment of CpGs that are significant at a genome-wide significance level (P < 1.4 × 10−11), and gray bars represent enrichment of CpGs that are significant at a gene-level significance level (P < 1.2 × 10−7). BivFlnk, flanking bivalent TSS/enhancer; Enh, enhancer; EnhBiv, bivalent enhancer; EnhG, genic enhancer; Het, heterochromatin; Quies, quiescent; ReprPC, repressed polycomb; ReprPCWk, weak repressed polycomb; TssA, active TSS; TssAFlnk, flanking active TSS; TssBiv, bivalent/poised TSS; Tx, strong transcription; TxFlnk, weak transcription; ZNF/Rpts, ZNF genes and repeats