Fig. 2

Screening of sequencing data from LUND1 shows preservation of host and pathogen DNA. a Krona plots reflecting the metagenomic composition of the lung nodule. The majority of sequencing reads were aligned to Homo sapiens (n = 2,833,403), demonstrating extensive preservation of host DNA. A small portion of reads aligned to bacterial organisms, and 80% of these reads were assigned to the MTBC node (n = 1724). b Damage plots generated from sequencing reads mapped directly to a reconstructed MTBC ancestor genome [21], demonstrating a pattern characteristic of ancient DNA