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Fig. 7 | Genome Biology

Fig. 7

From: Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Fig. 7

Model of inter- vs. intra-enhancer compensation. Top: at a gene regulated by many redundant enhancers, enhancers are free to show directional cis-trans effects because there is ample opportunity for crosstalk between enhancers, leading to inter-enhancer compensation. Bottom: at a gene regulated by very few enhancers, individual enhancers show compensatory cis-trans effects (intra-enhancer) because there is less opportunity for crosstalk between enhancers

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