Fig. 1

CTCF binding site enrichment at gene promoters. Density of CTCF binding sites and their features around 7747 gene promoters bearing at least one of 8846 CTCF binding sites computed as the averages in 10-bp bins. All panels are centred on the gene transcription start sites (Ensembl v72). The window starts on the left (− 2 kb) and ends in the gene body on the right (+ 2 kb). Genes are stratified in four equal subsets based on their expression values (Read Per Kilobase per Million reads, RPKM) in macrophages [4]; the shading of each line reflects the expression level. We first show a the density of CTCF binding sites, then b their average motif score computed by HOMER, then c their average ChipSeq score computed from the 33 ENCODE NarrowPeak tracks and finally d the ratios of average motif and ChipSeq scores for each bin