Fig. 1
From: Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics
Factors that determine the number of zeros in scRNA-seq data. a Total UMI counts per cell, which range from 746 to 17,302 with average 3819 UMIs per cell, are plotted against the number of zeros per cell. Color coding indicates the individual cell types as determined by data-driven clustering. The proportion of variance in the number of zeros that is explained by the total UMI count per cell (R2= 0.947) was computed based on fitting a loess regression to the data (blue curve). b The per-gene rates of expression (μg), which range from 0.23 to 97.4 with average 1.51 UMI/10K, are plotted against the number of zeros per gene. Genes that were identified as zero-inflated by scRATE (1 SE) are indicated in dark blue