Skip to main content
Fig. 7 | Genome Biology

Fig. 7

From: Splicing-accessible coding 3′UTRs control protein stability and interaction networks

Fig. 7

Frameshift-inducing alternative splicing generates protein isoforms with diverse functionalities. Alternative splicing of penultimate exons frequently extends the upon reading frame into the supposed 3′UTR. The resulting protein variants are identical to the full-length versions except a novel C-terminus. The novel C-termini are enriched in proline and PxxP motifs (top). This can (1) destabilize the resulting protein, (2) destabilize the protein together with interaction partners, and (3+4) modify protein-protein interactions

Back to article page