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Fig. 3 | Genome Biology

Fig. 3

From: Polymorphic mobile element insertions contribute to gene expression and alternative splicing in human tissues

Fig. 3

Overview of the sQTL analysis in ME-only analysis. a Number of detected sQTLs with Benjamini-Hochberg FDR < 10% in each tissue. Bars are colored by tissue clusters based on cis-eQTL as shown in b (tree). b Similarity (Spearman’s correlation coefficient ρ) between different tissues based on cis-sQTL (lower triangle) and PSI values (upper triangle). ASE-pMEI pairs with FDR < 10% in at least one tissue are selected for the analysis. The tree was based on the hierarchical clustering of the cis-sQTL results, and the branches are colored to four groups. Tissue text colors in a and b were based on the hierarchical clustering tree of PSI results (data not shown). c The relationship between the sQTL count (FDR < 10%) and the individual count in different tissues. The axes are in log scale. d ASE-pMEI pair count and the number of tissues they were detected as significant for events internal or at the edge of the gene. Tissue text is colored by tissue clusters based on cis-sQTL in b (tree). e Effect size (beta values) distribution for ASEs internal or at the edge of different pMEIs. Tissue abbreviations are the same as in Fig. 1

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