Table 2 Ten selected PWAS-exclusive associations
Phenotype | Gene symbol | Chrom | Generalized q value | Dominant q value | Dominant r/Cohen’s d | Recessive q value | Recessive r/Cohen’s d |
|---|---|---|---|---|---|---|---|
HLS reticulocyte % of red cells | IL6 | 7 | 1.8E−126 | 1 | n.s. | 7.3E−128 | − 0.043 |
Hip circumference (BMI adjusted) | SLC39A8 | 4 | 1.1E−23 | 1.6E−22 | − 0.019 | 0.00081 | − 0.0083 |
Eosinophil counts | FOXP1 | 3 | 2.6E−16 | 0.89 | n.s. | 9.8E−17 | − 0.016 |
Intraocular pressure | FOXG1 | 14 | 2.7E−14 | 1 | n.s. | 2.6E−15 | 0.031 |
Lymphocyte counts | INPP1 | 2 | 3.4E−12 | 0.5 | n.s. | 1.9E−12 | − 0.014 |
Eosinophil counts | CD80 | 3 | 3.1E−06 | 0.97 | n.s. | 1.1E−06 | − 0.01 |
Intraocular pressure | GAPT | 5 | 4.4E−06 | 1 | n.s. | 6.5E−07 | − 0.021 |
Red cell distribution width | MLLT3 | 9 | 1.2E−05 | 0.76 | n.s. | 8.5E−06 | − 0.01 |
Chronic lymphocytic leukemia | FAM160B1 | 10 | 0.0033 | 0.99 | n.s. | 0.048 | 0.06 |
Intraocular pressure | CLVS2 | 6 | 0.0043 | 0.98 | n.s. | 0.0018 | 0.016 |