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Fig. 6 | Genome Biology

Fig. 6

From: PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins

Fig. 6

PWAS and SKAT provide complementary results. a Number of significant genes detected by PWAS, SKAT, and the consensus of both, across the 49 tested phenotypes (over the same cohorts derived from the UKBB). Phenotypes are sorted by the highest of the three numbers. b An evidence score of gene-phenotype associations (derived from Open Targets Platform) is shown across phenotypes by its average over the significant genes detected by PWAS, SKAT, or the consensus of both. The numbers of significant genes (over which the averaging is performed) are shown over the bars. c Comparison of the FDR q values obtained by PWAS and SKAT over 4944 gene-phenotype associations with strong support by Open Targets Platform. d A similar comparison over 202 associations reported by OMIM to have a known molecular basis. The right plot (marked by red frames) is a zoom-in of the left

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