Fig. 4

Localized amplifications of chr13q34/IRS2 exist across numerous tumor types. a Heatmaps display copy number alterations across chromosome 13 for indicated tumor types (blue = copy number loss, red = copy number gain). Inset shows molecular features for the subset of 50 GBMs with the highest IRS2 copy number level. b Kaplan-Meier survival analysis of proneural subtype glioblastomas from the TCGA project shows an inverse correlation between IRS2 expression and survival (p = 0.013).