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Table 1 Genes reciprocally regulated by Tug1 lncRNA in the testes

From: The Tug1 lncRNA locus is essential for male fertility

Gene name Location Mean TPM Significance Biological process
WT KO Rescue WT-KO KO-Rescue
Pard3b chr1 2.66 2.13 2.74 *** *** Microtubule cytoskeleton organization
Nav1 chr1 1.40 2.33 1.45 ** ** Microtubule bundle formation
Gm28181 chr1 10.81 4.63 9.39 *** ** Unknown
Col5a1 chr2 7.16 8.97 7.85 * * Cell adhesion
Hoxd10 chr2 2.17 4.43 2.23 * * Regulation of transcription
Sulf2 chr2 12.20 16.74 13.21 *** ** Metabolic process
Amy1 chr3 16.43 23.06 14.58 * *** Metabolic process
Dhcr24 chr4 30.92 43.38 34.72 *** * Lipid metabolic process
Tmem176a chr6 17.89 25.23 16.32 ** *** Lipid metabolic process
Nat8f5 chr6 2.30 4.78 2.13 ** ** System development
Nat8 chr6 9.57 16.53 8.23 ** *** Glutathione metabolic process
Apoc1 chr7 35.49 56.71 37.27 *** ** Lipid metabolic process
Vmn1r181 chr7 2.65 4.26 1.88 ** *** Unknown
Klk1b27 chr7 12.21 31.01 2.65 *** *** Proteolysis
Klk1b21 chr7 23.81 56.40 5.45 *** *** Proteolysis
Klk1b24 chr7 19.20 34.33 5.95 * *** Proteolysis
Cd209f chr8 1.57 2.64 1.23 * *** Cell adhesion
Gpt2 chr8 25.46 33.70 24.06 ** *** Biosynthetic process
Tug1 chr11 40.08 0.89 1.60 *** ***
Spns2 chr11 6.30 7.92 6.47 * * Sphingolipid metabolic process
Serpina3n chr12 4.10 13.85 7.18 *** *** Inflammatory response
Ankrd9 chr12 43.02 50.58 44.74 * * Post-translational protein modification
Sv2c chr13 5.59 7.53 5.15 *** *** Transmembrane transport
3110070M22Rik chr13 110.87 93.69 120.25 ** * Unknown
Tmem267 chr13 87.89 77.92 92.25 *** *** Unknown
Il17rb chr14 4.20 6.08 3.65 *** *** Regulation of cell growth
Stab1 chr14 3.99 5.50 4.04 ** * Cell adhesion
Selenop chr15 88.40 130.97 85.90 *** *** Selenium compound metabolic process
C7 chr15 94.22 128.27 91.48 ** *** Immune response
Aqp2 chr15 4.93 13.17 6.48 *** *** Water transport
AU021092 chr16 30.38 44.08 33.37 *** * Unknown
Nrros chr16 3.00 3.93 2.99 * * Superoxide metabolic process
Mrap chr16 4.83 8.21 4.75 *** *** Protein localization to plasma membrane
Cyp21a1 chr17 1.99 3.12 1.22 * *** Steroid metabolic process
Ston1 chr17 28.51 34.85 29.11 *** *** Regulation of endocytosis
Stk32a chr18 1.22 2.78 1.50 *** *** Protein phosphorylation
mt-Rnr1 chrM 211.26 253.11 219.24 * * Ribosome biogenesis
  1. List of genes with TPM ≥ 1 and significant changes in the expression between wild-type (WT), Tug1−/− (KO), and Tug1rescue testes. Chromosomal location of the genes, mean TPM for each condition, and the main biological processes associated with each gene are listed. Significance of the fold change between wild-type versus Tug1−/− (WT-KO) and Tug1−/− versus Tug1rescue (KO-Rescue) is indicated by asterisks (*p < 0.05; **p < 0.01, ***p < 0.001)