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Table 1 Genes reciprocally regulated by Tug1 lncRNA in the testes

From: The Tug1 lncRNA locus is essential for male fertility

Gene name

Location

Mean TPM

Significance

Biological process

WT

KO

Rescue

WT-KO

KO-Rescue

Pard3b

chr1

2.66

2.13

2.74

***

***

Microtubule cytoskeleton organization

Nav1

chr1

1.40

2.33

1.45

**

**

Microtubule bundle formation

Gm28181

chr1

10.81

4.63

9.39

***

**

Unknown

Col5a1

chr2

7.16

8.97

7.85

*

*

Cell adhesion

Hoxd10

chr2

2.17

4.43

2.23

*

*

Regulation of transcription

Sulf2

chr2

12.20

16.74

13.21

***

**

Metabolic process

Amy1

chr3

16.43

23.06

14.58

*

***

Metabolic process

Dhcr24

chr4

30.92

43.38

34.72

***

*

Lipid metabolic process

Tmem176a

chr6

17.89

25.23

16.32

**

***

Lipid metabolic process

Nat8f5

chr6

2.30

4.78

2.13

**

**

System development

Nat8

chr6

9.57

16.53

8.23

**

***

Glutathione metabolic process

Apoc1

chr7

35.49

56.71

37.27

***

**

Lipid metabolic process

Vmn1r181

chr7

2.65

4.26

1.88

**

***

Unknown

Klk1b27

chr7

12.21

31.01

2.65

***

***

Proteolysis

Klk1b21

chr7

23.81

56.40

5.45

***

***

Proteolysis

Klk1b24

chr7

19.20

34.33

5.95

*

***

Proteolysis

Cd209f

chr8

1.57

2.64

1.23

*

***

Cell adhesion

Gpt2

chr8

25.46

33.70

24.06

**

***

Biosynthetic process

Tug1

chr11

40.08

0.89

1.60

***

***

–

Spns2

chr11

6.30

7.92

6.47

*

*

Sphingolipid metabolic process

Serpina3n

chr12

4.10

13.85

7.18

***

***

Inflammatory response

Ankrd9

chr12

43.02

50.58

44.74

*

*

Post-translational protein modification

Sv2c

chr13

5.59

7.53

5.15

***

***

Transmembrane transport

3110070M22Rik

chr13

110.87

93.69

120.25

**

*

Unknown

Tmem267

chr13

87.89

77.92

92.25

***

***

Unknown

Il17rb

chr14

4.20

6.08

3.65

***

***

Regulation of cell growth

Stab1

chr14

3.99

5.50

4.04

**

*

Cell adhesion

Selenop

chr15

88.40

130.97

85.90

***

***

Selenium compound metabolic process

C7

chr15

94.22

128.27

91.48

**

***

Immune response

Aqp2

chr15

4.93

13.17

6.48

***

***

Water transport

AU021092

chr16

30.38

44.08

33.37

***

*

Unknown

Nrros

chr16

3.00

3.93

2.99

*

*

Superoxide metabolic process

Mrap

chr16

4.83

8.21

4.75

***

***

Protein localization to plasma membrane

Cyp21a1

chr17

1.99

3.12

1.22

*

***

Steroid metabolic process

Ston1

chr17

28.51

34.85

29.11

***

***

Regulation of endocytosis

Stk32a

chr18

1.22

2.78

1.50

***

***

Protein phosphorylation

mt-Rnr1

chrM

211.26

253.11

219.24

*

*

Ribosome biogenesis

  1. List of genes with TPM ≥ 1 and significant changes in the expression between wild-type (WT), Tug1−/− (KO), and Tug1rescue testes. Chromosomal location of the genes, mean TPM for each condition, and the main biological processes associated with each gene are listed. Significance of the fold change between wild-type versus Tug1−/− (WT-KO) and Tug1−/− versus Tug1rescue (KO-Rescue) is indicated by asterisks (*p < 0.05; **p < 0.01, ***p < 0.001)
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Genome Biology

ISSN: 1474-760X

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