Fig. 4

Predicted increase in the dependency of tumors on genes with somatic mutations. a Distribution of TCGA tumor versus normal prediction scores derived from different classifiers under the CRISPR (upper) and RNAi (lower) screening models. b Differential dependency on genes that carry hetLOF (left) or homoLOF (right) mutations in mutant (blue or red) versus wild-type (gray) samples. c Differential dependency on non-TSGs (left) or TSGs (right) that carry LOF mutations in mutant (green or brown) versus wild-type (gray) samples. d Differential dependency on genes that carry GOF mutations (left) or on known oncogenes (OG) that carry only silent mutations (right) in mutant (orange or violet) versus wild-type (gray) samples. b–dP values attached to the density plots are based on the Kolmogorov–Smirnov test. P values over the box plots are from Student’s t test