Fig. 8

TFBS prediction performance. a An illustration of TFBS prediction in an example genomic region. The region contains a genomic bin with ELF1 motif and high SCATE-reconstructed CRE activity in GM12878. The bin is predicted as a ELF1 binding site. The prediction can be validated by ELF1 ChIP-seq peak in GM12878. b An example sensitivity versus FDR curve for comparing different methods for predicting ELF1 TFBSs in an analysis that pools 25 GM12878 cells. c Two examples (ELF1 in GM12878 and JUND in K562) that illustrate the method comparison across different cell numbers. In each example, analyses are performed by pooling different numbers of cells. The median AUC under the sensitivity-FDR curve from 10 independent cell samplings is shown as a function of pooled cell number. d The averaged AUC across all TFs is shown as a function of pooled cell number in GM12878 and K562 respectively