Fig. 4
From: Single-cell ATAC-seq signal extraction and enhancement with SCATE
Adaptive tuning of analysis resolution. The number of CRE clusters automatically chosen by SCATE via cross-validation (histogram) is compared with the true optimal CRE cluster number determined by external information from the gold standard bulk DNase-seq data (dots). Different plots correspond to different cell types and pooled cell number. In each plot, the histogram shows the CRE cluster number chosen by SCATE in 10 independent cell samplings. The dots show the true correlation between the gold standard bulk DNase-seq signal and the SCATE-reconstructed scATAC-seq signal (both at log-scale) at each CRE cluster number, averaged across the 10 cell samplings. The dot with the highest correlation is the true optimal cluster number