Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: An evolutionary driver of interspersed segmental duplications in primates

Fig. 2

LCR16a-associated chromosomal evolutionary rearrangements in marmoset. a A chromosome ideogram schematic from marmoset chromosome 11 (CJA11) is compared to human and the predicted primate ancestor (PA). Synteny blocks are distinguished by colors and numbers while the position of the FISH probe is depicted by a red mark. The colored arrows indicate evolutionary inversions, and black arrows denote the ancestral orientation. A ~ 33 Mbp pericentromeric inversion in marmoset (green) is defined at the centromeric boundary by an LCR16a-associated duplication block. Both the predicted primate ancestor and human (chr11q22.2-q25) are shown to be in direct orientation based on the order of the blocks analyzed in other primate lineages [15]. b A complex chromosomal rearrangement on marmoset chromosome 5 (CJA5) is identified between the ancestral chromosomes of HSA17 and HSA13; again LCR16a defines the boundary of this event. Note that the evolutionary order of the two inversions that led to HSA17 is unknown and the sequence shown in the figure is only one of two possibilities. c Single-color FISH analysis using metaphase spreads is used to confirm the presence of chromosomal rearrangements between marmoset and human. A probe mapping to the telomeric region of HSA11 (RP11-265F9) shows a signal mapping to a syntenic region at the CJA11 centromere. At CJA5, two adjacent FISH signals from (RP11-481P7 and RP11-110 K18) map to the ancestral telomeric region of HSA17 and the centromeric region of HSA13. CJA, Callithrix jacchus; HSA, Homo sapiens; PA, primate ancestor; NC, neocentromere

Back to article page