Fig. 4

The influence of chromatin state on methylation divergence. a MET (top) and JSD (bottom) profiles over regions defined by different chromatin states for rosettes. The profile comprises 2-kb flanks and color-codes the arithmetic mean in non-overlapping, 50-bp bins. b Hierarchical clustering of JSD (rosette) with chromatin accessibility signals using Spearman’s ρ over non-overlapping, 50-kb intervals. Wherever applicable, replicate signals have been averaged. c Hierarchical clustering of JSD (rosette) with histone marks. The H3K9me2 signal is log2(H3K9me2/H3) as in [32]. d Mean JSD in regions characterized by positive (x-axis) and negative (y-axis) HiC-eigenvalues (e). The dots indicate the observed pair of values for different C contexts (color-coded) and all sources (not annotated). The kernel density estimates (small ellipses) represent the corresponding random distributions for reshuffled genomic bins. The dashed bisecting line divides the plane into regions of higher JSD in compacted (CSDs) and loose (LSDs) structural domains as defined in [33]