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Fig. 4 | Genome Biology

Fig. 4

From: Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer

Fig. 4

Naïve-like B cells inhibit the cell growth in lung cancer. a Naïve-like B cells inhibit cell growth of A549 cells. The left panel showed the experimental design. The cell growth of A549 cells co-cultured with or without CD20+ B cells was determined by CCK8 assays (right panel). b Naïve-like B cells inhibit cell growth of A549 cells in a cell-cell interaction-independent manner. The left panel showed the experimental design. The cell growth of A549 cells treated with or without culture supernatants of CD20+ B cells was determined by CCK8 assays (right panel). c t-SNE plots showing the expression and distribution of SERPINA9, VNN2, IFI30, and PIK3AP1 in single-cell RNA-seq analysis of lung tumor. d Determination of VNN2 and SERPINA in the culture media of naïve-like B cells from patients’ tissues. B cells isolated from PBMC were used as control (ctrl). e Overexpression of VNN2, IFI30, PIK3AP1, and SERPINA9 inhibited the cell growth of A549 cells

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