Fig. 5

Dynamic 3D chromatin looping interactions identified using 3DeFDR-5C, 3DLRT, and ANOVA. a Reference interaction score heatmaps for two sample loci. b Loop classification results achieved with each differential looping detection method at a target false discovery rate (FDR) of 2%. c Enrichment of cell-type specific markers in loops classified as NPC or ES-2i & ES-serum for each of the three methods at a target FDR of 2%. d Log fold-change in percent CTCF orientation among loops classified as constitutive, ES-2i & ES-serum, or NPC, over percent CTCF orientation among loops classified as background