Fig. 3

Simulated 5C datasets exhibit strong similarity to experimental 5C datasets. a, b Heatmaps of relative 5C interaction frequency in the genomic regions surrounding the a Klf4 and b Olig1/2 genes are shown for simulations and real experimental data. c, d Heatmaps of interaction scores in the genomic regions surrounding the c Klf4 and d Olig1/2 genes are shown for simulations and real experimental data. e Matrices of pairwise Spearman’s correlations between real and simulated 5C replicates after conditional quantile normalization (see the “Methods” section)