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Fig. 8 | Genome Biology

Fig. 8

From: Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation

Fig. 8

Cell cycle regulation controls EHT. a Cell cycle marker genes identified in the scRNA-seq dataset were used to determine the cell cycle profile of individual clusters upon inhibition of distinct CDKs. b Proposed model for the role of cell cycle during EHT. Endothelial cells need to re-enter the cell cycle in order to progress through EHT and generate functional HPCs. Additionally, endothelial cells lose their haemogenic potential if cell cycle entry and progression is prevented upon transient cell cycle block. The process is regulated by CDKs, which are necessary for EHT and for the acquisition of HPC differentiation potential

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