Fig. 7

Effect of CDK inhibitors evaluated by single-cell transcriptomics. Samples were treated with different cell cycle inhibitors, namely PD0332991 (CDK4/6i), Roscovitine (CDK2/1i), and R03306 (CDK1i), or with DMSO (CTRL). At EHT D5, cells were collected and processed for scRNA-seq. Data from the four samples was merged and clustered. a tSNE plots showing previously identified cell populations, on the merged samples (top row) and for each treatment separately (bottom row). b Pie charts showing the percentage and absolute number of cells for each condition