Fig. 2
From: Dynamic rewiring of the human interactome by interferon signaling
Mapping the interactome of IFN-stimulated cells by SEC-PCP-SILAC. a Schematic overview of the SEC-PCP-SILAC workflow. b PCP chromatograms of housekeeping proteasome and immunoproteasome-specific proteins in stimulated and unstimulated cells. c PCP chromatograms of mitochondrial F1F0–ATPase complex proteins in stimulated and unstimulated cells. d Complete set of PCP chromatograms passing quality control in PrInCE (n = 1520) defined by heavy/light ratio, arranged by index of maximum protein abundance, from a representative biological replicate. e Protein-protein interaction adjacency matrix for all 27,694 interactions with a precision greater than 70%, colored by interaction precision. Insets show adjacency matrices of known protein complexes from the CORUM database [28]