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Fig. 6 | Genome Biology

Fig. 6

From: Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

Fig. 6

caQTL and clQTL rs2692224 regulate chromatin accessibility and chromosomal interaction at CAD gene FN1. aFN1 locus, showing caQTL and clQTL rs2692224. b Bar graphs show allele-specific enrichment of chromatin accessibility at rs2692224 as identified by allele-specific qPCR. c mRNA levels and d chromatin accessibility at the TSS region of FN1 were suppressed by CRISPRi-KRAB targeting at rs2692224. e Diagram (top) shows the chromosomal loops between rs2692224 and TSS/TES of FN1. 3C-PCR (bottom) indicates the differential chromosomal contacts from rs2692224 to TSS of FN1. Pre-post: allele frequencies in the QTL regression data. Shown are means ± SD; n = 3; ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05

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