Fig. 6From: Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal loopingcaQTL and clQTL rs2692224 regulate chromatin accessibility and chromosomal interaction at CAD gene FN1. aFN1 locus, showing caQTL and clQTL rs2692224. b Bar graphs show allele-specific enrichment of chromatin accessibility at rs2692224 as identified by allele-specific qPCR. c mRNA levels and d chromatin accessibility at the TSS region of FN1 were suppressed by CRISPRi-KRAB targeting at rs2692224. e Diagram (top) shows the chromosomal loops between rs2692224 and TSS/TES of FN1. 3C-PCR (bottom) indicates the differential chromosomal contacts from rs2692224 to TSS of FN1. Pre-post: allele frequencies in the QTL regression data. Shown are means ± SD; n = 3; ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05Back to article page