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Fig. 3 | Genome Biology

Fig. 3

From: Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

Fig. 3

SMC relevant transcription factors are colocalized with QTLs. Results from HOMER reference motif scanning on ± 50-bp windows surrounding a bQTLs and b caQTLs. Allele-specific motif scanning with flipped SNPs in ± 20-bp windows surrounding c bound-vs-less-bound bQTLs, d open-vs-closed caQTLs, and e closed-vs-open caQTLs. f Heatmaps show the bQTL, caQTL, and clQTL densities at TCF21 peaks, ATAC peaks, JUN peaks, SRF peaks, and AHR:ARNT binding motifs. ***P < 10−8; **P < 10−4; *P < 10−2; n.sP > 0.01. g Heatmaps show the ATACseq open chromatin (ATAC), histone H3K27ac (K27ac), and H3K4me1(K4me1) mark enrichment at bQTLs, caQTLs, and clQTLs in ± 5-kb windows. h Density plot showing open chromatin, H3K27ac, and H3K4me1 enrichment at chromosomal loop anchors (yellow area within dashed lines). i Boxplots show differences between the enrichments of open chromatin, H3K27ac, and H3K4me1, on chromosomal loop anchors with and without clQTLs

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