TY - JOUR AU - Ramesh, Naveen AU - Sei, Emi AU - Tsai, Pei Ching AU - Bai, Shanshan AU - Zhao, Yuehui AU - Troncoso, Patricia AU - Corn, Paul G. AU - Logothetis, Christopher AU - Zurita, Amado J. AU - Navin, Nicholas E. PY - 2020 DA - 2020/07/06 TI - Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing JO - Genome Biology SP - 162 VL - 21 IS - 1 AB - Investigating genome evolution in response to therapy is difficult in human tissue samples. To address this challenge, we develop an unbiased whole-genome plasma DNA sequencing approach that concurrently measures genomic copy number and exome mutations from archival cryostored plasma samples. This approach is applied to study longitudinal blood plasma samples from prostate cancer patients, where longitudinal tissue biopsies from the bone and other metastatic sites have been challenging to collect. SN - 1474-760X UR - https://doi.org/10.1186/s13059-020-02045-9 DO - 10.1186/s13059-020-02045-9 ID - Ramesh2020 ER -