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Fig. 3 | Genome Biology

Fig. 3

From: CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data

Fig. 3

Visualization interface of FusionEditor for curating fusions predicted from one sample. a Table view which shows the five “HQ” (high quality) in-frame fusions predicted in an infant ALL (SJINF011_D). A 3-gene fusion involving AFF1-RAD51B-KMT2A is recognized automatically and marked by a box labeled as “multi-seg.” The reciprocal KMT2A-AFF1 fusion was also identified as a HQ in-frame fusion. Inter-and intra-chromosomal fusions are labeled with red and black text, respectively. Known fusions are labeled with purple text (e.g., KMT2A-AFF1 and FLT3 ITD in this case). b Graphical view depicting the breakpoints on the protein domains of the three partner genes. Additional information such as the chimeric reads ratio for each fusion breakpoint is shown to support assessing the validity of each predicted fusion

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