Fig. 2

Fusion detection using CICERO. a Overview of CICERO algorithm which consists of fusion detection through analysis of candidate SV breakpoints and splice junction, fusion annotation, and ranking; key data sets used in each step are labeled. b Workflow of fusion detection. A user can submit an aligned BAM file or a raw fastq file as the input on a local computer cluster or on St. Jude Cloud. The raw output can be curated using FusionEditor and final results can be exported as a text file