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Fig. 7 | Genome Biology

Fig. 7

From: Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae

Fig. 7

“Shooting Gallery” model for initiation by Pol II scanning in Saccharomyces cerevisiae. PIC assembly upstream of TSS region initiates a scanning process whereby TSSs are moved toward the PIC by DNA translocation putatively through TFIIH DNA translocase activity. Initiation probability will be determined in part by DNA sequence (the size of the indicated “targets”), Pol II catalytic activity, and the processivity of scanning, as well as constraints of TSSs being too close to the PIC. Our data are consistent with this mechanism acting at all yeast promoters and enable interpretation of how alterations to Pol II catalytic activity, TFIIF function, or TFIIB function alter initiation probability at all TSSs

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