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Fig. 3 | Genome Biology

Fig. 3

From: Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes

Fig. 3

Comparison of rates of NCCMs associated with key GBM genes versus all other protein-coding genes. a Boxplot depicting the amount of non-coding constraint mutations per kbp for key GBM genes versus all OPCGs shows a significantly higher rate of alteration (t test, P value < 0.0001). Median, the middle data point is represented as a gray line in the middle of the boxplot and the upper whiskers represent the maximum value within 1.5 * interquartile range of the upper quartile. b Rates of non-coding constraint mutation for key GBM genes compared to all other protein-coding genes show the fraction of genes occurring in different rates of alteration. c A total of 26 key GBM genes have ≥ 1 NCCM per 100 kbp. See the insert for the type of mutation

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