Fig. 5

APEC depicted the developmental pathways of Mus musculus thymocytes by pseudotime analysis. a Pseudotime trajectory based on the accesson matrix of thymocyte ftATAC-seq data. Cell colors were defined by the developmental stages along pseudotime. Pie charts show the proportion of cell clusters at each stage. b APEC scores of important marker genes (Cd8a, Cd4, Runx3, and Ccr7) along each branch of the pseudotime trajectory. c Weighted scores of important functional GO terms along each branch of the pseudotime trajectory. d Enrichment of specific motifs searched from the differential accessons of each cell subtype. e On the stage 2 branch, the cell number distribution of clusters DP.A1~A5 along pseudotime (upper panel) and the intensity of marker accessons of DP.A1 and DP.A3/4/5 (lower right panel) with top enriched GO terms with significance (lower left panel)