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Fig. 2 | Genome Biology

Fig. 2

From: APEC: an accesson-based method for single-cell chromatin accessibility analysis

Fig. 2

APEC improved the cell-type classification of adult mouse forebrain snATAC-seq data. a A tSNE diagram demonstrates the APEC clustering of forebrain cells. b Hierarchical clustering of the cell-cell correlation matrix. The side bar denotes cell clusters from APEC. c Average scores of the marker genes for each cell cluster generated by the method mentioned in the data source paper (Preissl et al. [10]) and normalized by the standard score (z-score). The top row lists the number of cells in each cluster. d Hierarchical clustering of the cluster-cluster correlation matrix. e Differential enrichments of cell-type-specific motifs in each cluster. f, g Fisher’s exact test between the differential genes of the excitatory (EX) and inhibitory (IN) neurons from snATAC-seq and the signature genes of the excitatory (Excl) and inhibitory (Int) neurons defined in inDrops-seq [38]. The heatmaps show the –log(P value) normalized by calculating the z-scores through each row and column

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